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A NEW METHOD OF SIMULATING HUMAN BRAIN IMMUNE CELLS

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The research, which was published in Cell on May 11, 2023, emphasises the significance of immune cell and brain interactions and advances knowledge of neurodegenerative and developmental illnesses, including Alzheimer's disease and an autism spectrum disorder.  Microglia, specialised brain immune cells, are located at the interface between the human immune system and the brain and are critical in both development and illness. Microglia are unquestionably important, yet modelling and analysing them has remained challenging. Human microglia are challenging to research when taken out of the human-brain-like environment, in contrast to some human cells that can be examined outside of the body or in nonhuman models. Salk researchers created an organoid model, a three-dimensional collection of cells that resembles the characteristics of human tissues, to get around this obstacle. For the first time, using this model, scientists can examine the growth and operation of human microglia in r